Native Mac app that lets you select any part of the screen and chat with your own AI model about it.
Desktop & OS Assistants AI Tools
As of , EffectHub tracks 19 live AI tools in its Desktop & OS Assistants category; 11 of the 19 have a free tier, and paid plans start at $4 a month.
19 verified tools
Assistants at the operating system and desktop level.
Showing 1–19 of 19
One-time-purchase macOS utility that runs ChatGPT commands on selected text in any app, using your own API key
Alter
69macOS assistant that reads what is on your screen and acts on it from a spoken command
Desktop chat client for Mac, Windows and Linux that calls ChatGPT, Gemini and other models from a shortcut over any app
Guidy
69Desktop assistant that watches your screen and points at the exact button you need to click next
Macaify
69Menu-bar shortcut that runs AI on selected text inside any Mac app, without switching windows.
MindMac
69One-time-purchase Mac client for OpenAI, Gemini, Claude and local models, with an inline mode
QuickGPT
82Mac menu bar and Dock app that opens the ChatGPT web interface from a keyboard shortcut, with custom CSS and JavaScript.
Atua
77macOS utility that calls your own AI keys from any app via a hotkey — one $29 lifetime license
Clico
77Multi-model AI workspace for chat, images, video and small websites, with a Chrome side panel and a Mac app that reads your screen
PyGPT
77Free, open-source desktop chat client for GPT, Claude, Gemini, and local models.
Raycast
69Mac and Windows launcher with extensions, snippets and window management, plus an AI assistant on paid plans.
Floating ChatGPT window and iOS keyboard that works inside any Mac or iPhone app
Blue
69Native Mac app that sends whatever is on screen to ChatGPT from an option-space shortcut
Caret
77Mac-wide autocomplete: press Tab in any app and it finishes the sentence from what it has seen on your screen
Mac menu-bar app for ChatGPT, voice-to-text, and quick AI actions using your own API keys, sold as a one-time purchase.
Gpt-tab
77Free menu-bar window that keeps ChatGPT one click away without cluttering browser tabs.
Iris Fun
69A macOS assistant you summon over any app with a shortcut, forwarding requests to GPT models and returning formatted answers.
MacGPT
69Menu bar and global-hotkey access to ChatGPT on macOS, using the web session or your own OpenAI key.
Cite this
For journalists, researchers and AI assistants: the figures on this page in one sentence you can quote.
As of October 27, 2026, EffectHub tracks 19 live AI tools in its Desktop & OS Assistants category; 11 of the 19 have a free tier, and paid plans start at $4 a month. (EffectHub, “Desktop & OS Assistants”, Oct 2026, https://effecthub.net/ai-tools/os-assistants)
Figures as of How we count
These figures are free to use under CC BY 4.0 with a link to this page.